Animal Testing Book Extract, Edited Version
Moncek et al. (2004) compared the stress response of male Wistar rats
kept under varioius conditions to gentle 1-minute handling
of male Wistar ratsOne set of rats was
kept in groups of three or four animals in barren cages, with while the other subjects
were taken from groups of ten animals living in
five times larger cages that were
five times larger and
that wereenriched with various toys, tunnels, swings
and running wheels. The large-group/, enriched rats
from large groups showed a
significantly lower ACTH, corticosterone and adrenaline response to handling than the
small-group/, nounenriched rats
from small groups.
It is not clear whether the stress buffering effect was
exerted bydue to the larger number of group members, the larger space available to each subject, the enrichment, or
, (as is presumably the case)
a combination of these factors.
Belz et al. (2003) studied jugular vein-cannulated,
individually housed female Sprague-Dawley rats who lived in 1100 cm2
large cages that were either barren or enriched with rubber toys for gnawing and squares of compressed cotton fiber for shredding.
TheWhile living space was the same for all animals, but
those of in enriched cages
were not only were easier to handle but they also showed a significantly lower endocrine [adrenocorticotropin] stress response to intraperitoneal injection. This effect could not be verified in male rats. Sharp et al. (2005) assessed cardiovascular stress responses to common handling procedures in SH rats bearing radiotelemetry transmitters, who were individually housed in 930 cm2 large cages that were either barren or enriched with a simulated burrow, a feeding enrichment gadget Note to author:
if another adjective
is necessary, find a different one. Double use of 'enrichment' in this sentence is
confusing., and a shredding-and-nesting item. While blood pressure was not affected by enrichment, heart rate responses to subcutaneous injection and to
tail vein injection were significantly lower in enriched versus non-unenriched rats, indicating that enrichment had a stress buffering effect during these common procedures. This effect could not be replicated in Sprague-Dawley rats.